Mesenchymal Stem Cells Derived via Reprogramming of Old Cells Exhibit a Transcriptomic Signature Closer to that of Younger Cells and Pluripotent Cells

In today’s open access paper and publicity materials, researchers report on an assessment of induced mesenchymal stem cells (iMSCs) derived from induced pluripotent stem cells (iPSCs). The iPSCs were produced via the usual approach of reprogramming from tissue samples taken from old adults. The researchers then compared the gene expression profiles of these iMSCs with similar MSCs taken from fetal and adult tissues. They declare the the profile to be rejuvenated in comparison to that of the adult MSCs, but I think one has to be careful when using that word. We might better call the profile reflective of reprogramming, in that while it has commonalities with the fetal MSCs, it also has has commonalities with the iPSCs, expression of proteins usually not found in adult cells

From https://www.fightaging.org/archives/2019/04/mesenchymal-stem-cells-derived-via-reprogramming-of-old-cells-exhibit-a-transcriptomic-signature-closer-to-that-of-younger-cells-and-pluripotent-cells/

from
https://healthnews010.wordpress.com/2019/04/23/mesenchymal-stem-cells-derived-via-reprogramming-of-old-cells-exhibit-a-transcriptomic-signature-closer-to-that-of-younger-cells-and-pluripotent-cells/